Schizophrenia research papers


Unlike the dementias, schizophrenia has no classic histopathologic features readily identifiable with standard light microscopic assessments. Rather, postmortem studies of schizophrenia reported over the past 30 years have strongly suggested that this disorder involves subtle changes in the wiring of corticolimbic circuits, particularly the dorsolateral prefrontal cortex, anterior cingulate region, hippocampus, amygdala, and basal ganglia. Abnormalities in the synaptic connectivity within regions-of-interest, such as the hippocampus, can theoretically alter the integration of neural elements found within its microcircuits and result in abnormalities in their activity and the functional output.

As postmortem studies have suggested ways in which neural circuitry changes may contribute to abnormal integration at the micro-level, magnetic resonance MR and other forms of technology used to study behavior and cognition have been providing parallel and complementary views of how the metabolism of brain regions are altered and can influence the interactions within broad-based regional networks of the brain in live human subjects both with and without schizophrenia.

The Schizophrenia Section of Frontiers in Psychiatry is actively pursuing an integrative understanding of the neuroscience of schizophrenia by assembling a distinguished team of neuroscientists representing a broad range of strategies and technologies who will serve as Associate Editors. The goal of this Section will be to provide a forum for interactions among scientists, so that an integrative approach to studies of schizophrenia will eventually achieve a comprehensive view of how cognitive and emotional behaviors altered in schizophrenia may be perturbed by changes in the cellular and molecular integrity of key brain areas involved in the mediation of cognition and emotion.

All manuscripts must be submitted directly to the section Schizophrenia, where they are peer-reviewed by the Associate and Review Editors of the specialty section. Articles published in the section Schizophrenia will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article.

This is referred to as " democratic tiering ". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Psychiatry.

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For all queries regarding manuscripts in Review and potential conflicts of interest, please contact psychiatry. For queries regarding Research Topics, Editorial Board applications, and journal development, please contact psychiatry frontiersin. Toggle navigation. Login Register Login using. You can login by using one of your existing accounts. Therefore, it is extremely difficult to know whether schizophrenia caused certain stresses or occurred as a result of them. Marijuana and LSD are known to cause schizophrenia relapses. Additionally, for people with a predisposition to a psychotic illness such as schizophrenia, usage of cannabis may trigger the first episode.

Some researchers believe that certain prescription drugs, such as steroids and stimulants, can cause psychosis.

npj: Schizophrenia

With proper treatment, patients can lead productive lives. Treatment can help relieve many of the symptoms of schizophrenia. However, the majority of patients with the disorder have to cope with the symptoms for life. Psychiatrists say the most effective treatment for schizophrenia patients is usually a combination of:. Anti-psychosis drugs have transformed schizophrenia treatment. Thanks to them, the majority of patients are able to live in the community, rather than stay in a hospital. The primary schizophrenia treatment is medication.

Sadly, compliance following the medication regimen is a major problem. People with schizophrenia often come off their medication for long periods during their lives, at huge personal costs to themselves and often to those around them. The patient must continue taking medication even when symptoms are gone.

Otherwise they will come back.

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The first time a person experiences schizophrenia symptoms, it can be very unpleasant. They may take a long time to recover, and that recovery can be a lonely experience. It is crucial that a person living with schizophrenia receives the full support of their family, friends, and community services when onset appears for the first time. Previously, there were a number of subtypes of schizophrenia; these included, paranoid schizophrenia , paranoid schizophrenia, and schizoaffective disorder.

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Today, these subtypes are not used by doctors. For a more detailed explanation of why they are not used, read our article " Types of schizophrenia: What are they and are they still used? A schizophrenia diagnosis is reached by observing the actions of the patient. If the doctor suspects possible schizophrenia, they will need to know about the patient's medical and psychiatric history. Certain tests will be ordered to rule out other illnesses and conditions that may trigger schizophrenia-like symptoms, such as:.

This is an American Psychiatric Association manual used by healthcare professionals to diagnose mental illnesses and conditions.

Schizophrenia - causes, symptoms, diagnosis, treatment & pathology

The doctor needs to exclude other possible mental health disorders, such as bipolar disorder or schizoaffective disorder. It is also important to establish that the signs and symptoms have not been caused by, for example, a prescribed medication or substance abuse. Schizophrenia is when someone has unusual expressions or perceptions of reality.

Nowadays, it is seen as one condition rather than different types…. Frank , Ernst R. Berndt , Alisa B. Development of the American Economy. Economic Fluctuations and Growth. International Finance and Macroeconomics. International Trade and Investment.


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